Platelet Derived Growth Factor (PDGF) And Tumor
Platelet derived growth factor is an angiogenic factor isolated from human platelets. Platelet derived growth factor receptor is a member of the tyrosine protein kinase family. It can promote cell chemotaxis, division and proliferation in physiological processes such as growth and development, wound repair, etc. As one of the angiogenic factors, PDGF released by tumor cells can induce the proliferation and migration of vascular endothelial cells, smooth muscle cells and tumor cells, and inhibit their apoptosis.
In recent years, angiogenesis has been considered to play an important role in the occurrence, development, invasion and metastasis of tumors. Tumor blood vessels are the pathological basis of tumor growth and metastasis. On the one hand, tumors obtain nutrition and oxygen from the host through tumor blood vessels, and on the other hand, they transport metastatic cells to the host through tumor blood vessels, and continue to grow and induce angiogenesis in other parts of the body, leading to tumor metastasis. PDGF released by tumor cells can induce the proliferation and migration of vascular endothelial cells, smooth muscle cells and tumor cells, inhibit their apoptosis, and play a direct role in tumor angiogenesis. PDGF can also indirectly promote angiogenesis by inducing the expression of VEGF and indirectly promote tumor cell growth.
Overexpression of PDGF and its receptor is one of the common characteristics of tumors. High levels of PDGF and its receptors can be detected in breast cancer, cervical cancer, endometrial cancer, skin cancer, gastric cancer, colorectal cancer, lung cancer, pancreatic cancer, prostate cancer, ovarian cancer and other tumor cells. breast cancer cells can produce PDGF, stimulate the proliferation of adjacent fibroblasts with PDGF receptors, cause the formation of connective tissue in the tumor, and support the growth, invasion and metastasis of tumor cells, This is also one of the common features of breast cancer. PDGF promotes the occurrence and development of tumors through autocrine and paracrine signaling mechanisms. Overexpression of PDGF and its receptor by autocrine may lead to osteosarcoma, lung cancer, glioma, and neuroblastoma. Human sarcoma and glioma can abnormally secrete PDGF, which acts on tumor cells and leads to abnormal proliferation. PDGF autocrine signal not only provides tumor cell proliferation stimulation, but also has the ability to promote tumor cell invasion and metastasis in some epithelial tumors.
The expression of PDGFR is closely related to invasion, lymph node and distant metastasis of gastric cancer and clinical stage, but not to tumor size and histological classification. It can be concluded that the higher the expression of PDGFR, the easier the tumor metastasis.
Therefore, it is of great significance to detect the content of platelet-derived growth factor (PDGF) rapidly and efficiently for monitoring the proliferation and metastasis of tumor cells. At present, Wuxi Donglin Science and Technology Development Co., Ltd. has developed a variety of Elisa products related to platelet-derived growth factor to help researchers in need quickly and accurately determine the content of PDGF in the organism and help the research process. If you want to know about PDGF Elisa reagent, you can directly visit our website:
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In recent years, angiogenesis has been considered to play an important role in the occurrence, development, invasion and metastasis of tumors. Tumor blood vessels are the pathological basis of tumor growth and metastasis. On the one hand, tumors obtain nutrition and oxygen from the host through tumor blood vessels, and on the other hand, they transport metastatic cells to the host through tumor blood vessels, and continue to grow and induce angiogenesis in other parts of the body, leading to tumor metastasis. PDGF released by tumor cells can induce the proliferation and migration of vascular endothelial cells, smooth muscle cells and tumor cells, inhibit their apoptosis, and play a direct role in tumor angiogenesis. PDGF can also indirectly promote angiogenesis by inducing the expression of VEGF and indirectly promote tumor cell growth.
Overexpression of PDGF and its receptor is one of the common characteristics of tumors. High levels of PDGF and its receptors can be detected in breast cancer, cervical cancer, endometrial cancer, skin cancer, gastric cancer, colorectal cancer, lung cancer, pancreatic cancer, prostate cancer, ovarian cancer and other tumor cells. breast cancer cells can produce PDGF, stimulate the proliferation of adjacent fibroblasts with PDGF receptors, cause the formation of connective tissue in the tumor, and support the growth, invasion and metastasis of tumor cells, This is also one of the common features of breast cancer. PDGF promotes the occurrence and development of tumors through autocrine and paracrine signaling mechanisms. Overexpression of PDGF and its receptor by autocrine may lead to osteosarcoma, lung cancer, glioma, and neuroblastoma. Human sarcoma and glioma can abnormally secrete PDGF, which acts on tumor cells and leads to abnormal proliferation. PDGF autocrine signal not only provides tumor cell proliferation stimulation, but also has the ability to promote tumor cell invasion and metastasis in some epithelial tumors.
The expression of PDGFR is closely related to invasion, lymph node and distant metastasis of gastric cancer and clinical stage, but not to tumor size and histological classification. It can be concluded that the higher the expression of PDGFR, the easier the tumor metastasis.
Therefore, it is of great significance to detect the content of platelet-derived growth factor (PDGF) rapidly and efficiently for monitoring the proliferation and metastasis of tumor cells. At present, Wuxi Donglin Science and Technology Development Co., Ltd. has developed a variety of Elisa products related to platelet-derived growth factor to help researchers in need quickly and accurately determine the content of PDGF in the organism and help the research process. If you want to know about PDGF Elisa reagent, you can directly visit our website:
http://www.dldevelop.com/research-reagent/dl-pdgfaa-hu.html
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Wuxi Donglin Science and Technology Development Co., Ltd. will also continue to make efforts to produce higher quality products, provide fast and effective detection methods, and contribute to the research of fighting cancer.
